ARA-290
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Description
ARA-290 (also known as Cibinetide) is a non-erythropoietic peptide engineered from erythropoietin (EPO) that’s being studied for tissue protection, inflammation control, and neuropathic symptom relief – particularly small-fiber neuropathy in conditions like sarcoidosis or diabetes. Unlike full EPO, ARA-290 was designed to avoid stimulating red-blood-cell production, focusing instead on cytoprotection and immune modulation. Early clinical and preclinical studies report improvements in neuropathic pain scores, small-fiber nerve measures, and broader anti-inflammatory effects.
Mechanism of Action
ARA-290 selectively activates the Innate Repair Receptor (IRR) – a heteromer of the EPO receptor (EPOR) and the β-common receptor (CD131). IRR signaling down-regulates pro-inflammatory cytokines, limits oxidative stress, and promotes pro-survival pathways and tissue repair, without triggering erythropoiesis. This IRR-targeted activity underpins observed benefits across nerve, renal, and cardiovascular injury models.
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Frequently Asked Questions
Peptides are short chains of amino acids that perform various bodily functions, such as stimulating growth, tissue regeneration, or enhancing cognitive functions.
Peptides activate specific receptors or biochemical pathways in the body, leading to the desired therapeutic effects.
Depending on the type of peptide, benefits include improved sexual function, muscle growth, reduced inflammation, enhanced cognitive functions, and more.
Results can be seen within a few weeks after starting the therapy, although this can vary based on individual patient characteristics and the specific peptide.
Possible side effects include mild irritation at the injection site, headaches, nausea, and others, depending on the specific peptide.
The recommended frequency of use depends on the specific peptide and can range from daily use to several times a week. Your doctor will provide specific recommendations.
Peptides are not recommended for individuals with certain medical conditions, pregnant or breastfeeding women. Always consult with your doctor before starting the therapy.